Jeffrey S. Barrett, Jeffrey Skolnik, Bhuvana Jayaraman, Dimple Patel, Peter Adamson Improving Study Design and Conduct Efficiency of Event-Driven Clinical Trials via Discrete Event Simulation: Application to Pediatric Oncology
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P. Johnson (1), H. Dai (2), S. Neelakantan (2), T. Tensfeldt (2) Optimal dose & sample-size selection for dose-response studies
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M.A. Fabre (2), E. Fuseau (2), P. Cohen, H. Ficheux (1). Selection of a dosing regimen with WST11 by Monte Carlo simulations, using PK data collected after single IV administration in healthy subjects and population PK modelling.
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Kayode Ogungbenro and Leon Aarons Sample Size Calculations for Repeated Binary Population Pharmacodynamic Experiments
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Marylore Chenel1, Kayode Ogungbenro2, François Bouzom1 Comparison of uniresponse and multiresponse approaches of PopDes to optimize sampling times for drug-drug interaction studies: application to a Servier compound.
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S. Retout (1, 2), C. Bazzoli (1), E. Comets (1), H. Le Nagard (1), F. Mentré (1, 2) Population designs evaluation and optimisation in R: the PFIM function and its new features
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Ivelina Gueorguieva and Kimberley Jackson Prospective application of a multivariate population optimal design to determine parent and metabolite pharmacokinetic sampling times in a Phase II study.
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C. Bazzoli (1), S. Retout (1, 2), F. Mentré (1, 2) Population design in nonlinear mixed effects multiple responses models: extension of PFIM and evaluation by simulation with NONMEM and MONOLIX
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A. Russu (1), M. Neve (2), G. De Nicolao (1), I. Poggesi (2), R. Gomeni (2) Population methods for dose escalation studies: an MCMC approach
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Marcella Petrone, Stefano Zamuner, Vincenzo Di Iorio, Roger Gunn, Marc Laruelle and Roberto Gomeni Model-based sequential human PET study design for Optimal PK/RO assessment
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Anthe S. Zandvliet (1), Jan H.M. Schellens (2,3), William Copalu (4), Jantien Wanders (4), Mats O. Karlsson (5), Jos H. Beijnen (1,2), Alwin D.R. Huitema (1) Phase I study design of indisulam: evaluation and optimization
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Zexun Zhou, Marc Pfister, and Amit Roy Optimal Sampling Design and Trial Simulation using POPT and NONMEM
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